SYNTHESIS AND BIOLOGICAL ACTIVITY OF N-ACYL ANABASINE AND CYTISINE DERIVATIVES WITH ADAMANTANE, PYRIDINE AND 1,2-AZOLE FRAGMENTS

Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents.All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity.The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the Pulse Sensor

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Gender-violence and health care: How health system can step in

Gender-violence ACN also known as domestic violence, domestic abuse, spousal abuse or intimate partner violence, can be broadly defined as a pattern of abusive behaviors by one or both partners in an intimate relationship such as marriage, dating, family, friends or cohabitation.It can manifest as physical aggression, sexual abuse, emotional abuse,

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An Arthroscopic Modification of Coracoclavicular Ligament Reconstruction and Distal Clavicle Fracture Fixation in the Lateral Position

Distal clavicle fractures and acromioclavicular injuries are common shoulder injuries.Despite the frequency of these Cockrings injuries, there is no gold standard for treatment.Recent suspensory fixation techniques have minimized the amount of hardware required for surgical treatment of both acromioclavicular separations and distal clavicle fractur

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Comparative transcriptome-wide identification and differential expression of genes and lncRNAs in rice near-isogenic line (KW-Bph36-NIL) in response to BPH feeding

Brown planthopper (BPH) is the most devastating pest of rice in Asia, causing substantial yield losses and has become a challenging task to be controlled under field conditions.Although extensive measures have been taken over the past decades, which resulted in the evolution of new resistant BPH strains.Therefore, besides other possible approaches,

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